Yeruusaalem, 20 Abriil, 2026 (TPS-IL) — Saynisyahanada Israa'iil ayaa ku dhawaaqay in "fure" unugyada maqaarka ah oo caawiya unugyada maqaarka inay ilaashadaan aqoonsigooda ay go'aamin karto in nooc caadi ah oo kansarka maqaarka ah uu sii ahaado mid la daweyn karo ama uu noqdo mid aad u daran oo faafa.
Daraasadda Jaamacadda Cibraaniga ee Yeruusaalem waxay diiradda saartay kansarka maqaarka ee 'cutaneous squamous cell carcinoma' (cSCC), oo ah kan labaad ee ugu badan ee kansarka maqaarka adduunka. Qaybtani waxay noqon kartaa mid soo duushay oo ku faaftay xubnaha kale, taasoo ka dhigaysa aqoonsiga hore ee burooyinka halista sare leh caqabad weyn oo dhanka daawada ah. Adduunka oo dhan, waxaa la rumaysan yahay in cSCC uu saameeyo malaayiin qof sannad kasta, inkastoo tirooyinka saxda ah ay adag tahay in la helo maadaama wadamada badan aysan si nidaamsan u diiwaan galin kansarka maqaarka ee aan ahayn melanoma.
Cilmi-baarayaal ay hoggaaminayso ardayda PhD Tirza Bidany-Mizrahi oo uu hoos imanayo Prof. Rami I. Aqeilan, oo la shaqaynayay la-hawlgalayaal ka socda Talyaaniga, ayaa ogaaday waddo unugyada ah oo ku salaysan borotiin la yiraahdo WWOX. Kooxdu waxay ku tilmaameen WWOX "ilaaliye" aqoonsiga unugyada epithelial - oo ah xaalad deggan oo ilaalinaysa unugyada maqaarka inay qabtaan shaqadooda qaabkooda caadiga ah, ee nidaamsan.
Daraasadda ayaa muujinaysa in WWOX ay degsiiso borotiin kale oo muhiim ah, p63, oo ah maamule sare oo qaab-dhismeedka unugyada maqaarka iyo kala-soocidda. Marka WWOX uu joogo, heerarka p63 way degganaadaan oo unugyadu waxay ilaashadaan aqoonsigooda caadiga ah. Marka WWOX uu lumaayo, heerarka p63 si weyn ayay hoos ugu dhacaan, waxaana burburtaa degganaanshahaas.
Losing this cellular identity can trigger epithelial-to-mesenchymal transition (EMT), a process in which cells shed their fixed characteristics and gain the ability to migrate and invade surrounding tissues. In cancer, EMT is a critical step that enables tumor spread.
Soo-saarista ayaa lagu daabacay majaladda la qiimeeyay ee Proceedings of the National Academy of Sciences.
"Waxay daraasaddani ku soo kordhinayso waa habka xakamaynta sare," ayay sharaxeen cilmi-baarayaashu, iyagoo xusay in WWOX uu ka sarreeyo p63 ee nidaamka maamulkaas wuxuuna caawiyaa inuu ilaaliyo degganaantiisa, isagoo ka hortagaya isbeddelka keena soo duulista.
Mudanayaal, natiijada daraasadda ma aha oo kaliya moodooyinka tijaabada ah. Muunado burooyin bini'aadam ah, cilmi-baarayaashu waxay arkeen qaab joogto ah: marka cSCC uu u sii gudbo marxalado horumarsan, heerarka WWOX iyo p63 labadaba way hoos u dhaceen. Hoos u dhacaan isku xiran waxay soo jeedinayaan in dariiqa uu firfircoon yahay bukaannada oo aysan ahayn oo kaliya xaaladaha shaybaarka.
Nuxurka daraasadda ayaa ah in la ogaado WWOX–p63 axis oo ah maamule go'aaminaya in unugyada kansarka maqaarka ay ilaashadaan degganaanshaha ama ay helaan awoodda soo duulista, iyo in lagu xiro horumarka cudurka ee unugyada bini'aadamka. Cilmi-baarayaashu waxay soo jeedinayaan inay mustaqbalka caawin karto aqoonsiga bukaannada qaba halista sare ee cudurka daran iyo inay bixiso bartilmaameed cusub oo daaweyn loogu talagalay ka hortagga faafitaanka.
Hal codsi oo degdeg ah waa hagaajinta qiimeynta halista ee cSCC. Dhakhaatiirtu waxay hadda ku tiirsan yihiin cabbirka burooyinka, qoto dheerida, iyo histology si ay u qiyaasaan daran-nimada. Heerarka WWOX iyo p63 waxay ku dari karaan calaamad unugyada ah qaab-dhismeedkaas. Maadaama borotiinada labaduba ay hoos u dhacaan marka cudurka uu horumarayo, heerarka hoose waxay calaamad u noqon karaan in burooyinku ay horeyba u u guurayaan xaalad aad u soo duulaysa, taasoo u oggolaanaysa aqoonsi hore oo ah bukaannada halista sare leh iyo dabagalka dhow ama daaweyn xooggan.
Intaa waxaa dheer, maadaama isbeddelka EMT uu yahay habka ugu muhiimsan ee kansarrada epithelial badan, oo ay ku jiraan kuwa beerka, naasaha, mindhicirka, iyo madaxa iyo qoorta, natiijooyinku waxay kordhiyaan suurtagalnimada in dib loo soo celiyo shaqada WWOX ama la degsiisto p63 ay caawin karto in unugyada kansarku ay ku sii jiraan xaalad aan ahayn mid soo duulaysa.
Mawduucyada La Xiriira
