Yeruusaalem, 30 Sebtembar, 2025 (TPS-IL) — Muddo tobannaan sano ah, cilmi-baarayaashu waxay la yaabeen sababta nolosha ay ugu dul istaagtay kaliya 20 amino acids iyadoo ay jireen noocyo kale oo badan oo laga heli jiray dhulka hore. Daraasad Israa’iili ah oo la soo saaray Isniintii ayaa soo jeedinaysa inaysan ahayn wax kadis ah: xasilloonida isku-ururka molecules-ka ayaa u badan inay siiyeen “alpha amino acids” faa’iido horumarineed, taasoo bixisa sabab la tijaabin karo su’aal muddo dheer jirtay oo ku saabsan cilmi-baarista asalka nolosha.
Cilmi-baarista, oo uu hoggaaminayay Dr. Moran Frenkel-Pinter oo ka tirsan Jaamacadda Cibraaniga ee Yeruusaalem, ayaa tilmaamaysa in jawaabtu aysan ku jirin kaliya kiimikada laakiin ay ku jirto xasilloonida isku-ururka molecules-ka hore, taasoo siinaysa aragti cusub sida nolosha u dooratay waxyaabaha ay ka kooban tahay.
Frenkel-Pinter iyo kooxdeeda, oo ay ku jiraan Ms. Sarah Fisher iyo Mr. Yishi Ezerzer, ayaa daraaseeyay depsipeptides — molecules fudud oo la mid ah peptides-ka oo la aaminsan yahay inay si dabiici ah ugu samaysmaan dhulka hore. Si ka duwan peptides-ka casriga ah, depsipeptides-ka waxay ka kooban yihiin isku dhaf ah ester iyo amide bonds, taasoo ka dhigaysa inay si fudud ugu samaysmaan xaaladaha prebiotic laakiin ay ka yar yihiin kuwo xasilloon muddo dheer. Cilmi-baarayaashu waxay rabeen inay ogaadaan sababta loo doortay alpha amino acids marka loo eego xulashooyinka kale ee prebiotic ee badan sida beta ama gamma amino acids.
Si ay u ogaadaan, kooxdu waxay samaysay depsipeptides iyagoo isticmaalaya noocyo kala duwan oo hydroxy iyo amino acids ah waxayna u fiirsadeen sida ay iskooda isu ururinayaan. Natiijooyinka ayaa ahaa kuwo la yaab leh. Depsipeptides-ka laga dhisay alpha amino acids ayaa samaysmay isku-urur isku-uruursan oo u eg dhibic, kuwaas oo ku sii jiray kuwo xasilloon muddo toddobaadyo ah, xitaa ka dib markii la qaboojiyay oo la dhalaaliyay marar badan. Dhanka kale, isku-ururka beta-ku-saleysan ayaa ahaa kuwo aad uga yar xasilloon oo inta badan ku kala baxa dareeraha.
“Iskuururka iskii ah waa mid ka mid ah shuruudaha ugu muhiimsan ee nolosha,” ayuu yiri Dr. Frenkel-Pinter. “Natiijooyinkayagu waxay soo jeedinayaan in awoodda sare ee proto-peptides-ka ku salaysan alpha ee samaynta qaybo xasilloon ay siiyeen faa’iido horumarineed oo muhiim ah, taasoo u samaysay waddo la dhigto laf-dhabarta borotiinka aan ku aragno bayoolojiga maanta.”
Ardayda cilmi-baarista, helitaankaani waa guul cilmiyeed iyo mid shakhsi ah labadaba. “Su’aasha ah sababta horumarku u doortay qayb gaar ah oo amino acids ah ayaa ahayd mid qarsoon muddo aad u dheer,” ayuu yiri Yishi Ezerzer, oo ah ardayda master-ka oo si wada jir ah u hoggaaminaya mashruuca. “In la qaado xitaa hal tallaabo oo lagu jawaabayo su’aashan mudada dheer jirta waa wax la yaab leh, waxaana sharaf ii ah inaan wax ku biiriyo dadaalkan.”
Sarah Fisher waxay xoogga saartay muhiimadda guud ee natiijooyinka. “Waxaan halkan ku muujineynaa, markii ugu horeysay, awoodda depsipeptides-ka ee iskooda isu ururinta, oo la mid ah peptides-ka casriga ah. Inkastoo natiijooyinkan ay yihiin horumar weyn oo ku saabsan horumarka kiimikada, waxay sidoo kale ka caawin karaan meelaha sida daawooyinka, halkaas oo naqshadaynta qaababka peptide ee xasilloon ay tahay mid muhiim ah,” ayay tiri.
Iyadoo si toos ah loo barbar dhigayo laf-dhabarta alpha iyo beta proto-peptide, daraasadda ayaa soo jeedinaysa model ku salaysan isku-ururka asalka nolosha. Waxay soo jeedinaysaa in doorashada alpha amino acids aysan ahayn kaliya arrin la xiriirta helitaanka kiimikada, laakiin faa’iidada shaqada: molecules-ka samayn kara qaababka la mid ah qaybaha mudada dheer ah ayaa u badan inay badbaadaan oo ay horumaraan.
Wixii ka baxsan su’aasha asalka nolosha, fahamka mabda’yadan molecule-ka ayaa ka caawin kara naqshadaynta bayoolojiyada casriga ah, naqshadaynta daawooyinka, iyo nanotechnology.
Daraasadda waxaa lagu daabacay joornaalka dib loo eegay ee Proceedings of the National Academy of Sciences.
