Hore ayaa loo ogaan karaa Kansarka Naasaha: Cilmi-baaris Cusub oo Ka Timid Jaamacadda Cibraaniga
Yeruusaalem, 12 Janaayo, 2026 (TPS-IL) — Waxaa laga yaabaa in unugyada naasaha ee haweenka qaarkood ay muujiyaan calaamado muujinaya kansar mustaqbalka ah sanado ka hor inta aanu soo bixin buro kasta, taasoo u suurtagelin karta dhakhaatiirta inay si aad ah uga horeeyaan ogaanshaha kansarka naasaha — ama laga yaabaa inay ka hor istaagto inay soo baxdo, sida ay ku dhawaaqday Jaamacadda Cibraaniga ee Yeruusaalem.
Celcelis ahaan, hal haween ah midkiiba labaatanka (20) haween ah oo adduunka ah ayaa lagu ogaan doonaa kansarka naasaha, sida ay sheegtay Hay'adda Caafimaadka Adduunka (WHO).
Koox ka kooban saynisyahanno Israa'iili iyo Maraykan ah ayaa furay daaqad hore loo qarinayay oo ku saabsan sida kansarka naasaha ugu bilowdo haweenka qaba isbeddellada hidde-side ee BRCA1 ama BRCA2. Cilmi-baadhistu waxay muujinaysaa in xitaa ka hor inta aanu buro soo bixin, unugyada naasaha ee dadka qaba isbeddellada BRCA ay horay u muujiyaan qaab gaar ah oo "dhaawac meelo" ah oo DNA ah oo aad ugu eg qaababka jabka DNA-da ee lagu arko unugyada kansarka.
Daraasadda waxaa hoggaaminayay ardayda PhD-ga ah Sara Oster Flayshman iyadoo uu hagayo Professor Rami Aqeilan iyo Dr. Yotam Drier oo ka tirsan Kulliyadda Caafimaadka ee Jaamacadda Cibraaniga, iyadoo la kaashanayo Dr. Victoria Seewaldt iyo Dr. Mark LaBarge oo ka socda xarunta cilmi-baarista ee City of Hope ee California. Iyagoo isticmaalaya habka isku-xigxiga ee jiilka cusub, kooxdu waxay khariidad u sameeyeen jabyada laba-laab ee DNA-da (DSBs) ee guud ahaan hidde-side ee unugyada epithelial-ka naasaha ee aan malignant-ka ahayn ee ka yimid haweenka qaba isbeddellada hidde-side ee khatta sare leh.
Kooxdu waxay ogaatay in qaabka dhaawaca DNA-da ee unugyadan uu aad uga duwanaa waxa ay ku arkeen unugyada caafimaadka qaba, waxaana si la yaab leh, u eg qaababka lagu arko unugyada kansarka naasaha. Meelaha ugu badan ee saamaynta leh ee DNA-da ayaa ahaa kuwa la xiriira kansarka, gaar ahaan kuwa si caadi ah u firfircoon unugyada, taasoo ka dhigaysa inay u badan tahay inay keenaan kansar haddii la dhaawaco.
Daraasadda waxaa lagu daabacay majaladda cilmi-baarista ee la eegay ee Cell Death & Disease.
Professor Aqeilan wuxuu u sheegay The Press Service of Israel in muhiimadda daraasadda ay ku jirto xasillooni-darro hore oo unugyada ka horaysa kansarka.
"Helitaanka ugu weyn waa in unugyada epithelial-ka naasaha ee aan malignant-ka ahayn ee ka yimid haweenka khatta sare leh ay horay u muujiyaan 'jab-dhisme' gaar ah oo aan random ahayn marka la barbar dhigo kooxaha khatta celceliska ah, waxaana muhiim ah, in jab-dhismuhu uu qayb ahaan u eg yahay qaabka lagu arko unugyada kansarka naasaha," ayuu yiri. Jab-dhisme wuxuu tilmaamayaa qaabka dhamaystiran ama khariidadda jabyada DNA-da ee guud ahaan hidde-side ee unugga.
"Tani waxay soo jeedinaysaa in hababka la xiriira xasillooni-darrooyinka hidde-side ay socdaan si aad u hore, ka hor inta aanu buro soo bixin, iyo in daciifnimada hore ay dib u habayn karaan meesha ay ku ururaan jabyada DNA-da," ayuu yiri Aqeilan.
Cilmi-baarayaashu waxay xoojiyeen in qaababka jabka DNA-da lagu ogaan karo dadka dhallinyarada ah, ee aan kansarka lahayn, oo ay ku jiraan haweenka ka yar 35 jir. "Taas macnaheedu waa in isbeddelka la ogaan karo si aad uga horreeya kansarka caafimaad, iyo si macquul ah sanado, laga yaabo tobannaan sano, ka hor ogaanshaha dadka qaba cudurrada mustaqbalka," ayuu yiri Aqeilan. Inkasta oo daraasadda aysan bixinayn waqti sax ah oo lagu gaaro bilawga kansarka, waxay caqabad ku tahay aragtida dhaqameedka ah in dhacdooyinka luminta heterozygosity (LOH) ay yihiin tallaabada ugu horreysa ee malignancy.
Daraasadda waxay fureysaa waddooyin suurtagal ah oo loogu talagalay ogaanshaha hore.
"Shaqadani waxay bixisaa faham muhiim ah oo ku saabsan isbeddellada molecular-ka ugu horreeya ee ka dhaca unugyada naasaha ee haweenka khatta sare leh," ayuu Aqeilan u sheegay TPS-IL. "Fahamka dhacdooyinka hore wuxuu noo ogolaanayaa inaan u maleeyno istaraatiijiyado cusub oo lagu ogaanayo kansarka marxaladaha ugu horreeya, ee ugu daaweyn karo."
Drier wuxuu xusay in qaababkani ay "maalin maalmaha ka mid ah ay noo caawin karaan horumarinta biomarkers-ka saxda ah, si haweenka khatta sare leh aan loo ilaalin kaliya si waxtar leh, laakiin sidoo kale loo siiyo faragelin ku salaysan bayoolojiga dhabta ah ee unugyadooda."
Inkasta oo daraasadda hadda ay diiradda saarayso unugyada naasaha, Aqeilan wuxuu yiri tallaabooyinka xiga waxay baari doonaan haddii qaabab la mid ah ay ka soo baxaan unugyada kale ee u nugul kansarka.
"Baaritaanka unugyada ugxan-sidaha iyo tuubada Fallopian waa tallaabo macquul ah oo cad," ayuu u sheegay TPS-IL.
Intaa waxaa dheer, kooxdiisu waxay qorsheynayaan inay daraaseeyaan kooxo waaweyn oo haween ah muddo ka dib si ay u arkaan haddii qaababka dhaawaca DNA-da ee hore ay saadaalin karaan cidda ugu dambaynta yeelan doonta kansarka, iyo si ay u sahamiyaan tijaabooyinka aan xadgudubka lahayn ee ogaan kara qaababkan ka hor inta aanu buro samaysmin.
Fahamka jabyada DNA-da ee hore sidoo kale wuxuu iftiimin karaa sababta ay haweenka khatta sare leh u qaadaan kansarka halka kuwa kale aysan u qaadin. "Waxay u horseedi kartaa istaraatiijiyado cusub oo ka hortag ah oo bartilmaameedsanaya goboladan hidde-side ee nugul ka hor inta aanu kansarku bilaaban," ayuu yiri Aqeilan.
Mawduucyada La Xiriira
