Cinwaanka: Saynisyahanada Israa’iil iyo Jarmal oo Helay Sirta Ka-hortagga Kemotherabiga Kansarka
By Pesach Benson • Oktoobar 20, 2025
Yeruusaalem, 20 Oktoobar, 2025 (TPS-IL) — Daraasad cusub oo caalami ah oo ay hoggaaminayeen saynisyahanada Israa’iil iyo Jarmal ayaa shaacisay nidaam borotiin ah oo gacan ka geysan kara sharraxaadda sababta ay u jiraan bukaanada qaar ee kansarka malawadka oo aan uga jawaabin daawaynta kemotherabiga.
Soo-saarista, oo lagu daabacay joornaalka cilmi-baarista ee Molecular Oncology, ayaa furaysa albaabka daawayn gaar loo leeyahay oo ka waxtar badan mid ka mid ah kansarrada ugu dhimashada badan adduunka.
Kansarka malawadka ayaa ah sababta saddexaad ee ugu weyn ee dhimashada la xiriirta kansarka caalamka. Iyadoo ku xiran heerka cudurka, waxaa caadiyan lagu daaweeyaa isku-darka hababka, sida kemotherabi, daawaynta shucaaca, daawaynta difaaca jirka, qaliinka, daawaynta bartilmaameedka, iyo daryeelka gargaarka.
Inkastoo kemotherabiga uu weli yahay tiirka daawaynta, bukaanada badan waxay la kulmaan iska caabin daroogada ah oo xaddidaysa waxtarkeeda. Si loo fahmo sababta, saynisyahanada ka socda Jaamacadda Cibraaniga ee Yeruusaalem, University Medicine Magdeburg, iyo Jaamacadda Otto-von Guericke ayaa falanqeeyay unugyada burooyinka iyo unugyada caafimaadka qaba ee 32 bukaan oo qaba kansarka malawadka, iyagoo isku daray baaritaanka horumarsan, falanqaynta histology, iyo moodooyinka burooyinka ee ay sameeyeen bukaanada.
Kooxda — oo ay hoggaaminayeen Prof. Michal Linial, Prof. Or Kakhlon, iyo cilmi-baarista Keren Zohar oo ka socda Jaamacadda Cibraaniga, oo ay weheliyaan Prof. Ulf D. Kahlert iyo Dr. Marco Strecker oo ka socda University Medicine Magdeburg — ayaa ogaaday doorka muhiimka ah ee nidaam borotiin ah oo loo yaqaan cystine/glutamate transporter, ama Xc-. Nidaamkan ayaa ka caawiya unugyada kansarka inay maareeyaan walbahaarka oksaydhiga iyo inay iska caabiyaan dhimashada unugyada ee la qorsheeyay, taasoo u oggolaanaysa burooyinka inay ku badbaadaan kemotherabiga.
“Daraasaddeenu waxay muujineysaa awoodda isku-darka xogta gaarka ah ee bukaanada iyo moodooyinka shaqaynta,” ayuu yiri Linial. “Habkan ma aha oo kaliya inuu ogaado waxa ka dhigaya buro kasta oo bukaan gaar ah, laakiin wuxuu ina tusayaa meesha kansarku ugu nugul yahay.”
Cilmi-baarayaashu waxay diiradda saareen hidaha SLC7A11 (oo sidoo kale loo yaqaan xCT), kaasoo si joogto ah uga badnaa unugyada burooyinka. Isagoo la shaqeynaya hidaha lammaanaha ah, wuxuu sameeyaa Xc- transporter — hab-dhismeedka molecular oo u oggolaanaya unugyada kansarka inay nuugaan cystine oo ay soo saaraan glutamate, taasoo ilaalinaysa dheelitirka loo baahan yahay si ay ugu badbaadaan walbahaarka daawaynta.
Markii ay cilmi-baarayaashu burburiyeen nidaamkan gaadiidka ee shaybaarka iyo organoids-ka ay sameeyeen bukaanada, burooyinku waxay noqdeen kuwo u nugul kemotherabiga. Waxay sidoo kale ogaadeen “saameyn” borotiin ah oo gaar ah oo ku taal dusha unugyada burooyinka oo u adeegi karta sidii biomarker si loo saadaaliyo bukaanada u badan inay iska caabiyaan daawaynta caadiga ah.
“Soo-saaristaani waxay caawin kartaa naqshadaynta daawayn cusub oo labadaba ka waxtar badan oo ka gaar ah, iyadoo siineysa rajo bukaanada la tacaalaya cudurkaan wax duminaya,” ayuu yiri Kahlert.
Daraasadda ayaa sidoo kale xoojineysa muhiimadda ferroptosis, oo ah nooc ka mid ah dhimashada unugyada oo la qorsheeyay oo ay unugyada kansarku inta badan ka fogaadaan. Maadaama dariiqooyinka molecular-ka ee isku midka ah ay ku lug leeyihiin ilaalinta unugyada neerfaha, cilmi-baarayaashu waxay aaminsan yihiin in natiijadoodu ay saameyn ku yeelan karto kansarka malawadka, iyagoo u fidin kara daraasadaha kansarrada kale iyo cudurada neerfaha.
Sida ay sheegtay kooxda, falanqaynta bioinformatic-ka ee ay samaysay Keren Zohar ayaa ahayd mid muhiim u ah go’doominta arrimaha gaarka ah ee bukaanada ee sababa iska caabinta daroogada. Iyagoo isbarbardhigaya shaybaarka buro kasta iyo shaybaar caafimaad oo ka yimid isla bukaan, cilmi-baarayaashu waxay awoodeen inay ka gudbaan kala-duwanaanta dabiiciga ah ee u dhaxaysa burooyinka oo ay ogaadaan farqiyada molecular-ka ee saxda ah ee la xiriira natiijada daawaynta.
Soo-saaristaani waxay Xc- transporter u dhigaysaa sidii bartilmaameed daawayn oo la saadaalin karo waxayna xoojineysaa awoodda pharmacogenomics-ka gaarka loo leeyahay — daraasadda sida hidaha ay u saameeyaan jawaabta qofka ee daroogada — si loo hago daryeelka kansarka mustaqbalka.
“Inta aan sii fahanno ‘faraha’ molecular-ka ee qeexaya buro kasta, ayaa sii dhowaanaynaa daawaynta runtii ku habboon bukaanada, ma aha oo kaliya cudurka,” ayuu yiri Linial.
Soo-saaristaani waxay caawin kartaa dhakhaatiirta inay saadaaliyaan iska caabinta kemotherabiga, inay hagayaan daawaynta gaarka loo leeyahay, oo ay dhiirigeliyaan daroogo cusub oo xanniba da Xc- transporter. Maadaama dariiqooyinka isku midka ah ay saameyn ku leeyihiin badbaadada neerfaha, natiijada ayaa sidoo kale caawin karta cilmi-baarista cudurada neerfaha sida Alzheimer’s iyo Parkinson’s.
